Endometriome

The balance of bacteria in the endometrium is a key factor for successful embryo implantation. In normal conditions, in the endometrium are mainly present different bacterial species of the Lactobacillus genus.

The presence of dysbiotic or pathogenic bacteria may alter the endometrial microbiome and can disrupt the uterine environment, causing implantation failure and pregnancy loss.

Pathogenic bacteria: Staphylococcus, Streptococcus, Enterococcus, Mycoplasma, Ureaplasma, Enterobacteria (Escherichia, Klebsiella), Chlamydia and Neisseria. These bacteria cause infection, which is linked to implantation failure and recurrent miscarriage.

Dysbiotic bacteria: Bifidobacterium, Prevotella, Sneathia, Atopobium, Veillonella.Microbial imbalance is linked to embryo implantation failure.

As a new dimension of endometrial assessment to improve reproductive outcomes, Endometriome™ screening test can be applied. Endometriome™ is a screening test that evaluates the endometrial microbiome to improve the clinical management of infertile patients. The Endometriome™ test provides a complete view of the bacterial composition of the endometrium, reports the 10 most common bacteria in the endometrium, and identifies the 8 most common pathogens that cause chronic endometritis (CE). The Endometriome™ test can determine whether the uterine microbial environment is optimal for embryo implantation. Depending on the results, embryo transfer is recommended or, if necessary, antibiotic and probiotic therapy is prescribed to restore an optimal microbiome. The Endometriome™ test also detects bacteria-causing chronic endometritis and helps clinicians recommend appropriate antibiotic and probiotic treatments. Endometriome™ test: can be applied to assess the microbiological environment that the embryo will encounter in patients with recurrent insemination failure (RIF) or recurrent pregnancy loss (RPL) or any patient wishing to conceive.