FERTISCAN

INFERTILITY

A study by the Italian National Institute of Health indicates that infertility involves 15% of couples and equally affects males and females. About 10-15% of male infertility cases and 8-10% of female infertility cases are associated with genetic alterations, which can include chromosomal abnormalities or single gene mutations. 20% of the cases is defined as “idiopathic infertility” because it is not possible to certaintly diagnose the presence of underlying causes.

FertiScan™ is an innovative genetic test for the evaluation of the infertility genetic causes.
There are two lines of investigation:
FertiScan™ Female Infertility Panel
FertiScan™ Male Infertility Panel

GLOBAL FEMALE INFERTILITY PANEL

Female infertility panel is a test for the evaluation of women’s reproductive health, designed to identify female infertility most common genetic causes and the rarest genetic abnormalities associated with infertility and recurrent miscarriage.

The test includes simultaneous analysis of more than 70 genes for the study of female infertility main causes, including Primary Ovarian Insufficiency, Ovarian dysfunction, Ovarian dysgenesis, Embryonic lethality, Recurrent miscarriage and Oocyte maturation defects.

FertiScan™ Female:

Female Fertiscan tests are available in a targeted version for the investigation of specific disorders associated with an increased risk of infertility in women, and in a complete version through the Global Female Infertility Panel.

• Fertiscan ™ Global Female Infertility Panel 70 genes
• Fertiscan ™ - Primary Ovarian Insufficiency/Ovarian Dysfunction NGS Panel 50 genes
• FertiScan ™ - Ovarian Dysgenesis NGS panel 11 genes
• FertiScan ™ - Preimplantation embryonic lethality NGS Panel 3 genes
• FertiScan ™ - Oocyte maturation defect NGS panel 5 genes
• Fertiscan ™ - Miscarriage NGS panel 14 genes
• Fertiscan ™ - Polycystic Ovary Syndrome 2 genes
• Fertiscan ™ - Ovarian Hyperstimulation Syndrome / Ovarian response to Ovarian stimulation 5 genes

GLOBAL MALE INFERTILITY PANEL

Male infertility panel is a test for the evaluation of men’s reproductive health, designed to identify male infertility most common genetic causes.

The test includes simultaneous analysis of more than 50 genes for the study of male infertility main causes, including Azoospermia, Asthenospermia and abnormal sperm morphology.

FertiScan ™ Male:

FertiScan ™ Global Male Infertility Panel 50 genes

Indication To FertiScan ™:

• Conditions of recurrent miscarriage
• Couples with reproductive difficulties
• Multiple attempts at artificial insemination
• Couples who are approaching assisted reproductive technology pathways
• Family history of hereditary infertility conditions

High-Resolution Sequencing Technology

The genes included in the FertiScan™ panels* are entirely sequenced at high reading depth thanks to the use of Next Generation Sequencing (NGS) technologies. The analysis involves the complete study of the coding portion of each gene (full exon sequencing) at high resolution.

How The Test Works:

1. SAMPLE COLLECTION
2. DNA EXTRACTION
3. DNA SEQUENCING Next Generation Sequencing (NGS)
4. IDENTIFICATION OF DNA MUTATIONS
5. RESULTS

The genetic sequences obtained are interpreted by an advanced bioinformatic analysis, in order to identify any mutations associated with pathologies in the analyzed genes.

Fertiscan Characteristics

EASY Sample required: blood (3ml)
RELIABLE Sensitivity and specificity >99%
COMPLETE In-depth investigation to identify the genetic causes of infertility
ADVANCED State-of-the-art technologies and sophisticated bioinformatics analysis